Scientists uncover a hidden switch that helps cancer cells thrive

A protein once thought to simply help cancer cells avoid death turns out to do much more. MCL1 actively drives cancer metabolism by controlling the powerful mTOR growth pathway, tying survival and energy use together. This insight explains why MCL1-targeting drugs can be effective—but also why they sometimes damage the heart. Researchers have now identified a way to reduce that risk, potentially unlocking safer cancer therapies.

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Scientists uncover a hidden switch that helps cancer cells thrive

A protein once thought to simply help cancer cells avoid death turns out to do much more. MCL1 actively drives cancer metabolism by controlling the powerful mTOR growth pathway, tying survival and energy use together. This insight explains why MCL1-targeting drugs can be effective—but also why they sometimes damage the heart. Researchers have now identified a way to reduce that risk, potentially unlocking safer cancer therapies.

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Type 2 diabetes physically changes the human heart, study finds

Type 2 diabetes doesn’t just raise the risk of heart disease—it physically reshapes the heart itself. Researchers studying donated human hearts found that diabetes disrupts how heart cells produce energy, weakens the muscle’s structure, and triggers a buildup of stiff, fibrous tissue that makes it harder for the heart to pump. These changes are especially severe in people with ischemic heart disease, the most common cause of heart failure.

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Type 2 diabetes physically changes the human heart, study finds

Type 2 diabetes doesn’t just raise the risk of heart disease—it physically reshapes the heart itself. Researchers studying donated human hearts found that diabetes disrupts how heart cells produce energy, weakens the muscle’s structure, and triggers a buildup of stiff, fibrous tissue that makes it harder for the heart to pump. These changes are especially severe in people with ischemic heart disease, the most common cause of heart failure.

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Type 2 diabetes physically changes the human heart, study finds

Type 2 diabetes doesn’t just raise the risk of heart disease—it physically reshapes the heart itself. Researchers studying donated human hearts found that diabetes disrupts how heart cells produce energy, weakens the muscle’s structure, and triggers a buildup of stiff, fibrous tissue that makes it harder for the heart to pump. These changes are especially severe in people with ischemic heart disease, the most common cause of heart failure.

Read More